In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.
#DavidSinclair #Longevity #Lifespan
Thank you to our sponsors:
Athletic Greens - https://athleticgreens.com/sinclair
InsideTracker - https://insidetracker.com/sinclair
Levels - https://levels.link/sinclair
Our Patreon page:
https://www.patreon.com/davidsinclair
Lifespan book:
https://amzn.to/3sUqurT
Lifespan podcast website: https://www.lifespanpodcast.com
Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd
Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante
Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com
Timestamps:
00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge
00:02:39 Expressing Gratitude to the Sponsors
00:05:28 Testosterone Replacement Therapy
00:10:09 Human Growth Hormone
00:13:56 Peptide Supplementation and Regenerative Signaling
00:18:11 MOTS-c, Humanin, and Other Peptides
00:25:05 Exosome Therapy
00:31:56 A Primer on Stem Cells and Yamanaka Factors
00:37:59 Stem Cell Aging and Cord Blood Banking
00:41:42 The Therapeutic Potential of Stem Cells
00:43:37 Cellular Reprogramming
00:51:35 Resetting the Aging Clock
00:56:50 The Future Looks Bright
00:58:15 Next Week’s Episode: External Aging
00:58:36 Subscription and Support Options
Links:
Benefits and risks of testosterone treatment: https://bit.ly/35I3uTs
Eunuchs are long-lived: https://bit.ly/3ukL1GU
Longevity is enhanced in mice lacking growth hormone: https://go.nature.com/3AOTW4k
MOTS-c and age-dependent physical decline in mice: https://go.nature.com/34aUgi6
Fatty liver disease, obesity, and an analog of MOTS-C: https://bit.ly/3Ho7GFE
Humanin regulates lifespan and healthspan in mice: https://bit.ly/3Gy0lm1
Humanin ameliorates diabetes in mice: https://bit.ly/3ukiFw7
Mouse aging can be modulated via exosomes: https://go.nature.com/3oi0sM4
Exosomes and ulcer healing in older mice: https://bit.ly/3oEhPaf
Generating induced pluripotent stem cells: https://bit.ly/3APMypv
Vision loss after ocular injections: https://bit.ly/3L2yVIh
Mesenchymal stem cells and human frailty: https://bit.ly/3s6kzxX
Restoring vision loss in older mice: https://go.nature.com/335iysI
Reversing epigenetic age in humans: https://bit.ly/342XXGJ
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
#DavidSinclair #Longevity #Lifespan
Thank you to our sponsors:
Athletic Greens - https://athleticgreens.com/sinclair
InsideTracker - https://insidetracker.com/sinclair
Levels - https://levels.link/sinclair
Our Patreon page:
https://www.patreon.com/davidsinclair
Lifespan book:
https://amzn.to/3sUqurT
Lifespan podcast website: https://www.lifespanpodcast.com
Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd
Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante
Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com
Timestamps:
00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge
00:02:39 Expressing Gratitude to the Sponsors
00:05:28 Testosterone Replacement Therapy
00:10:09 Human Growth Hormone
00:13:56 Peptide Supplementation and Regenerative Signaling
00:18:11 MOTS-c, Humanin, and Other Peptides
00:25:05 Exosome Therapy
00:31:56 A Primer on Stem Cells and Yamanaka Factors
00:37:59 Stem Cell Aging and Cord Blood Banking
00:41:42 The Therapeutic Potential of Stem Cells
00:43:37 Cellular Reprogramming
00:51:35 Resetting the Aging Clock
00:56:50 The Future Looks Bright
00:58:15 Next Week’s Episode: External Aging
00:58:36 Subscription and Support Options
Links:
Benefits and risks of testosterone treatment: https://bit.ly/35I3uTs
Eunuchs are long-lived: https://bit.ly/3ukL1GU
Longevity is enhanced in mice lacking growth hormone: https://go.nature.com/3AOTW4k
MOTS-c and age-dependent physical decline in mice: https://go.nature.com/34aUgi6
Fatty liver disease, obesity, and an analog of MOTS-C: https://bit.ly/3Ho7GFE
Humanin regulates lifespan and healthspan in mice: https://bit.ly/3Gy0lm1
Humanin ameliorates diabetes in mice: https://bit.ly/3ukiFw7
Mouse aging can be modulated via exosomes: https://go.nature.com/3oi0sM4
Exosomes and ulcer healing in older mice: https://bit.ly/3oEhPaf
Generating induced pluripotent stem cells: https://bit.ly/3APMypv
Vision loss after ocular injections: https://bit.ly/3L2yVIh
Mesenchymal stem cells and human frailty: https://bit.ly/3s6kzxX
Restoring vision loss in older mice: https://go.nature.com/335iysI
Reversing epigenetic age in humans: https://bit.ly/342XXGJ
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
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